One chain local to me (Micro Center) did let you return opened software until last summer. They have been very lenient on what can be returned, and take back everything, hardware and software alike if you don't like it. (All "good" returns wind up in the bargin bins) However, it got way out of hand with the software, so you are now only allowed to exchange your return for the same software.

Piracy had dealt a death blow to being allowed to freely return software that didn't work, or didn't suit your needs.